Verification of Exposure to Cholinesterase Inhibitors: Generic Detection of OPCW Schedule 1 Nerve Agent Adducts to Human Butyrylcholinesterase
نویسندگان
چکیده
منابع مشابه
Verification of exposure to cholinesterase inhibitors: generic detection of OPCW Schedule 1 nerve agent adducts to human butyrylcholinesterase.
Phosphylated butyrylcholinesterase is one of the most important biomarkers to verify an exposure to nerve agents, and it can be analyzed with liquid chromatography-tandem mass spectrometry (LC-MS-MS) by detection of a phosphylated nonapeptide that results after digestion of butyrylcholinesterase (BuChE) with pepsin. For a sensitive analysis (low degree of BuChE inhibition), the identity of the ...
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ژورنال
عنوان ژورنال: Journal of Analytical Toxicology
سال: 2008
ISSN: 1945-2403,0146-4760
DOI: 10.1093/jat/32.1.125